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Benefits were more pronounced in studies using 6001,200mg per day over at least eight weeks.2 A 2022 randomized controlled trial in patients with metabolic syndrome found that 600mg of ALA daily for 12 weeks significantly reduced triglyceride levels and total cholesterol compared to placebo.59 However, the study did not observe significant changes in LDL-C or HDL-C

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Gut Permeability, Inflammation, and DAO Deficiency Gut permeability and inflammation can impact DAO (diamine oxidase) production and function, although they may not necessarily lead directly to a deficiency in DAO due to an excessive need for histamine metabolism